Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model
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چکیده
منابع مشابه
Cerebellar and Extracerebellar Involvement in Mouse Eyeblink Conditioning: the ACDC Model
Over the past decade the advent of mouse transgenics has generated new perspectives on the study of cerebellar molecular mechanisms that are essential for eyeblink conditioning. However, it also appears that results from eyeblink conditioning experiments done in mice differ in some aspects from results previously obtained in other mammals. In this review article we will, based on studies using ...
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The role of the ipsilateral cerebellum in human eyeblink conditioning was investigated using the 400-ms delay paradigm and testing 14 cerebellar patients (7 with unilateral lesions and 7 with bilateral lesions) and 20 control participants. Patients performed significantly worse with the ipsilesional eye than control participants but showed no difference when tested with (he contralesional eye. ...
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The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance of the cortex and the deep nuclei in motor learning/memory is not entirely clear. In this study, we show that the cerebellar cortex exerts both basal and stimulus-activated inhibition to the deep n...
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We have previously shown that intracerebellar infusion of the neuropeptide secretin enhances the acquisition phase of eyeblink conditioning (EBC). Here, we sought to test whether endogenous secretin also regulates EBC and to test whether the effect of exogenous and endogenous secretin is specific to acquisition. In Experiment 1, rats received intracerebellar infusions of the secretin receptor a...
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There is increasing evidence that, in addition to its major functional role in the regulation of fine motor control, the cerebellum is involved in other important functions, such as sensory-motor learning and memory. Classical conditioning of the eyeblink or nictitating membrane response (and other discrete behavioral responses) is a form of sensory-motor learning that depends crucially upon th...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2010
ISSN: 1662-5102
DOI: 10.3389/neuro.03.019.2009